› 5wj9

Electron Microscopy
3.49Å resolution

Human TRPML1 channel structure in agonist-bound open conformation

Released:
DOI: 10.2210/pdb5wj9/pdb
PDB entry 5wj9 coloured by chain, front view.
PDB entry 5wj9 coloured by chain, side view.
PDB entry 5wj9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human TRPML1 channel structures in open and closed conformations.
Schmiege P, Fine M, Blobel G, Li X
Nature 550 366-370 (2017)
PMID: 29019983
Related structures: EMD-8841

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190453 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucolipin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 580 amino acids
Theoretical weight: 65.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9GZU1 (Residues: 1-580; Coverage: 100%)
Gene names: MCOLN1, ML4, MSTP080, TRPML1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand AQV 4 x AQV
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.49Å
Relevant EMDB volumes: EMD-8841
Expression system: Homo sapiens

Quick links

Citations

26 review citations

Lysosomal Ion Channels as Decoders of Cellular Signals.
Li et al. (2019)
25 more

13 mentions without citation

Structural Pharmacology of TRP Channels.
Zhao et al. (2021)
12 more