› 5wrw

X-ray diffraction
2.91Å resolution

Structure of human apo-SRP72

Released:
DOI: 10.2210/pdb5wrw/pdb
PDB entry 5wrw coloured by chain, front view.
PDB entry 5wrw coloured by chain, side view.
PDB entry 5wrw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.
Gao Y, Zhang Q, Lang Y, Liu Y, Dong X, Chen Z, Tian W, Tang J, Wu W, Tong Y, Chen Z
J Mol Cell Biol 9 220-230 (2017)
PMID: 28369529

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131217 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Signal recognition particle subunit SRP72 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 163 amino acids
Theoretical weight: 18.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O76094 (Residues: 1-163; Coverage: 24%)
Gene name: SRP72
Sequence domains: Putative TPR-like repeat

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 83.435Å b: 123.715Å c: 150.723Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.266
Expression system: Escherichia coli

Quick links

Citations

10 citation in other articles

Structure of Rift Valley Fever Virus RNA-Dependent RNA Polymerase.
Wang et al. (2022)
9 more

3 mentions without citation

SRPassing Co-translational Targeting: The Role of the Signal Recognition Particle in Protein Targeting and mRNA Protection.
Kellogg et al. (2021)
2 more