› 5wvd

X-ray diffraction
3Å resolution

Structure of Mnk1 in complex with DS12881479

Released:
DOI: 10.2210/pdb5wvd/pdb
PDB entry 5wvd coloured by chain, front view.
PDB entry 5wvd coloured by chain, side view.
PDB entry 5wvd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.
Matsui Y, Yasumatsu I, Yoshida KI, Iimura S, Ikeno Y, Nawano T, Fukano H, Ubukata O, Hanzawa H, Tanzawa F, Isoyama T
Acta Crystallogr F Struct Biol Commun 74 156-160 (2018)
PMID: 29497019

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189732 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAP kinase-interacting serine/threonine-protein kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 310 amino acids
Theoretical weight: 34.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BUB5 (Residues: 37-382; Coverage: 66%)
Gene names: MKNK1, MNK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand 7UX 2 x 7UX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P43212
Unit cell:
a: 92.635Å b: 92.635Å c: 174.437Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.239 0.271
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain.
Yousuf et al. (2021)
1 more

4 mentions without citation

MNK Proteins as Therapeutic Targets in Leukemia.
Mazewski et al. (2023)
3 more