Function and Biology Details
Reaction catalysed:
Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero 25-mer (preferred)
PDBe Complex ID:
PDB-CPX-127065 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Apoptotic protease-activating factor 1
Molecule details ›
Chains: A, C, E, G, I, K, M
Length: 1248 amino acids
Theoretical weight: 142.02 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
Sequence domains:
Length: 1248 amino acids
Theoretical weight: 142.02 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
- Canonical:
O14727 (Residues: 1-1248; Coverage: 100%)
Sequence domains:
Cytochrome c
Molecule details ›
Chains: B, D, F, H, J, L, N
Length: 105 amino acids
Theoretical weight: 11.86 KDa
Source organism: Equus caballus
Expression system: Bacteria
UniProt:
Sequence domains: Cytochrome c
Length: 105 amino acids
Theoretical weight: 11.86 KDa
Source organism: Equus caballus
Expression system: Bacteria
UniProt:
- Canonical: P00004 (Residues: 1-105; Coverage: 100%)
Sequence domains: Cytochrome c
Apoptotic protease-activating factor 1
Molecule details ›
Chains: O, P, Q, R, W, X
Length: 102 amino acids
Theoretical weight: 11.58 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
Sequence domains: Caspase recruitment domain
Length: 102 amino acids
Theoretical weight: 11.58 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
- Canonical: O14727 (Residues: 1-102; Coverage: 8%)
Sequence domains: Caspase recruitment domain
Caspase-9 subunit p35
Molecule details ›
Chains: S, T, U, V, Y
Length: 100 amino acids
Theoretical weight: 11.7 KDa
Source organism: Homo sapiens
Expression system: Bacteria
UniProt:
Sequence domains: Caspase recruitment domain
Length: 100 amino acids
Theoretical weight: 11.7 KDa
Source organism: Homo sapiens
Expression system: Bacteria
UniProt:
- Canonical: P55211 (Residues: 1-100; Coverage: 24%)
Sequence domains: Caspase recruitment domain
