› 5wwg

X-ray diffraction
2.03Å resolution

Crystal structure of hnRNPA2B1 in complex with AAGGACUUGC

Released:
DOI: 10.2210/pdb5wwg/pdb
PDB entry 5wwg coloured by chain, front view.
PDB entry 5wwg coloured by chain, side view.
PDB entry 5wwg coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1.
Wu B, Su S, Patil DP, Liu H, Gan J, Jaffrey SR, Ma J
Nat Commun 9 420 (2018)
PMID: 29379020

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149687 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Heterogeneous nuclear ribonucleoproteins A2/B1 Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 21.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22626 (Residues: 12-195; Coverage: 52%)
Gene names: HNRNPA2B1, HNRPA2B1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
RNA (5'-R(*AP*AP*GP*GP*AP*CP*UP*U)-3') Chain: B
Molecule details ›
Chain: B
Length: 10 nucleotides
Theoretical weight: 3.2 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: C2
Unit cell:
a: 132.81Å b: 46.228Å c: 33.994Å
α: 90° β: 102.22° γ: 90°
R-values:
R R work R free
0.201 0.199 0.256
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

112 review citations

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism.
Yang et al. (2018)
111 more

2 mentions without citation

hnRNP A/B Proteins: An Encyclopedic Assessment of Their Roles in Homeostasis and Disease.
Thibault et al. (2021)
1 more