› 5x57

X-ray diffraction
1.45Å resolution

Structure of GAR domain of ACF7

Released:
DOI: 10.2210/pdb5x57/pdb
PDB entry 5x57 coloured by chain, front view.
PDB entry 5x57 coloured by chain, side view.
PDB entry 5x57 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics.
Ma Y, Yue J, Zhang Y, Shi C, Odenwald M, Liang WG, Wei Q, Goel A, Gou X, Zhang J, Chen SY, Tang WJ, Turner JR, Yang F, Liang H, Qin H, Wu X
Nat Commun 8 15375 (2017)
PMID: 28541346

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194025 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.42 KDa
Source organism: Homo sapiens
Expression system: bacterial endosymbiont of Idas sp.
UniProt:
  • Canonical: Q9UPN3 (Residues: 7113-7193; Coverage: 1%)
Gene names: ABP620, ACF7, KIAA0465, KIAA0754, KIAA1251, MACF1
Sequence domains: Growth-Arrest-Specific Protein 2 Domain

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21212
Unit cell:
a: 74.04Å b: 45.99Å c: 25.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.13 0.126 0.165
Expression system: bacterial endosymbiont of Idas sp.

Quick links

Citations

4 review citations

Impact of Epithelial Cell Shedding on Intestinal Homeostasis.
Ngo et al. (2022)
3 more

1 mention without citation

The microtubule quartet protein SNAP1 in Trypanosoma brucei facilitates flagellum and cell division plane positioning by promoting basal body segregation.
Souza Onofre et al. (2023)