› 5x9z

X-ray diffraction
7.31Å resolution

Crystal structure of inositol 1,4,5-trisphosphate receptor large cytosolic domain

Released:
DOI: 10.2210/pdb5x9z/pdb
PDB entry 5x9z coloured by chain, front view.
PDB entry 5x9z coloured by chain, side view.
PDB entry 5x9z coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography.
Hamada K, Miyatake H, Terauchi A, Mikoshiba K
Proc Natl Acad Sci U S A 114 4661-4666 (2017)
PMID: 28416699

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145968 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 2217 amino acids
Theoretical weight: 252.38 KDa
Source organism: Mus musculus
Expression system: Spodoptera
UniProt:
  • Canonical: P11881 (Residues: 1-2217; Coverage: 81%)
Gene names: Insp3r, Itpr1, Pcd6, Pcp1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: C2221
Unit cell:
a: 212.503Å b: 221.726Å c: 318.452Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.321 0.317 0.394
Expression system: Spodoptera

Quick links

Citations

16 review citations

Intracellular calcium release channels: an update.
Santulli et al. (2017)
15 more

2 mentions without citation

IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography.
Hamada et al. (2017)
1 more