› 5xah

X-ray diffraction
3Å resolution

Crystal structure of human Importin4

Released:
DOI: 10.2210/pdb5xah/pdb
PDB entry 5xah coloured by chain, front view.
PDB entry 5xah coloured by chain, side view.
PDB entry 5xah coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and Its Histone H3 Tail Binding.
Yoon J, Kim SJ, An S, Cho S, Leitner A, Jung T, Aebersold R, Hebert H, Cho US, Song JJ
J Mol Biol 430 822-841 (2018)
PMID: 29408485

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186260 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Importin-4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 416 amino acids
Theoretical weight: 45.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q8TEX9 (Residues: 668-1081; Coverage: 38%)
Gene names: IMP4B, IPO4, RANBP4
Sequence domains: HEAT-like repeat

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 24 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P21
Unit cell:
a: 64.92Å b: 110.769Å c: 126.82Å
α: 90° β: 106.5° γ: 90°
R-values:
R R work R free
0.231 0.226 0.28
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

5 review citations

H3-H4 Histone Chaperone Pathways.
Grover et al. (2018)
4 more

1 mention without citation

Research on the resistance of isoviolanthin to hydrogen peroxide-triggered injury of skin keratinocytes based on Transcriptome sequencing and molecular docking.
Wang et al. (2023)