› 5xwr

X-ray diffraction
2.69Å resolution

Crystal Structure of RBBP4-peptide complex

Released:
DOI: 10.2210/pdb5xwr/pdb
PDB entry 5xwr coloured by chain, front view.
PDB entry 5xwr coloured by chain, side view.
PDB entry 5xwr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.
Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, Hill J, Joy J, Yang H, Chai L, Sivaraman J, Tenen DG
Proc Natl Acad Sci U S A 115 E7119-E7128 (2018)
PMID: 29976840

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170754 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone-binding protein RBBP4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 443 amino acids
Theoretical weight: 49.98 KDa
Source organism: Homo sapiens
Expression system: Autographa californica nucleopolyhedrovirus
UniProt:
  • Canonical: Q09028 (Residues: 1-425; Coverage: 100%)
Gene names: RBAP48, RBBP4
Sequence domains:
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Sal-like protein 4 Chains: C, D
Molecule details ›
Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UJQ4 (Residues: 1-12; Coverage: 1%)
Gene names: SALL4, ZNF797

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 73.84Å b: 59.86Å c: 101.529Å
α: 90° β: 93.7° γ: 90°
R-values:
R R work R free
0.198 0.192 0.256
Expression systems:
  • Autographa californica nucleopolyhedrovirus
  • Not provided

Quick links

Citations

10 review citations

Antimicrobial Peptides as Anticancer Agents: Functional Properties and Biological Activities.
Tornesello et al. (2020)
9 more

1 mention without citation

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.
Liu et al. (2018)