Function and Biology Details
Reaction catalysed:
L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA +H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- p53 tumour suppressor family
- p53-like tetramerisation domain superfamily
- p53, DNA-binding domain
- Bromodomain
- p53, tetramerisation domain
- p53, central conserved site
- p53-like transcription factor, DNA-binding domain superfamily
- p53/RUNT-type transcription factor, DNA-binding domain superfamily
8 more domains
Structure analysis Details
Assemblies composition:
Assembly name:
Cellular tumor antigen p53 (preferred)
PDBe Complex ID:
PDB-CPX-138138 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone acetyltransferase p300
Molecule details ›
Chain: A
Length: 619 amino acids
Theoretical weight: 72.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 619 amino acids
Theoretical weight: 72.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
Q09472 (Residues: 1046-1664; Coverage: 26%)
Sequence domains:
Cellular tumor antigen p53
Molecule details ›
Chains: B, C, D, E
Length: 265 amino acids
Theoretical weight: 29.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 265 amino acids
Theoretical weight: 29.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P04637 (Residues: 92-356; Coverage: 67%)
Sequence domains:
