› 5y3s

X-ray diffraction
2.45Å resolution

Crystal structure of human NLRP1 leucine rich repeat domain

Released:
DOI: 10.2210/pdb5y3s/pdb
PDB entry 5y3s coloured by chain, front view.
PDB entry 5y3s coloured by chain, side view.
PDB entry 5y3s coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Jin T, Xiao TS

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189873 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 1, N-terminus Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 205 amino acids
Theoretical weight: 22.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9C000 (Residues: 790-990; Coverage: 14%)
Gene names: CARD7, DEFCAP, KIAA0926, NAC, NALP1, NLRP1
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

2 bound ligands:
Ligand PO4 2 x PO4
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: R32
Unit cell:
a: 141.48Å b: 141.48Å c: 294Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.212 0.259
Expression system: Escherichia coli

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