› 5y4m

X-ray diffraction
1.31Å resolution

Discoidin domain of human CASPR2

Released:
DOI: 10.2210/pdb5y4m/pdb
PDB entry 5y4m coloured by chain, front view.
PDB entry 5y4m coloured by chain, side view.
PDB entry 5y4m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition.
Liang W, Zhang J, Saint-Martin M, Xu F, Noraz N, Liu J, Honnorat J, Liu H
J Autoimmun 96 168-177 (2019)
PMID: 30337146

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193737 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Contactin-associated protein-like 2 Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 17.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UHC6 (Residues: 35-181; Coverage: 11%)
Gene names: CASPR2, CNTNAP2, KIAA0868
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

1 bound ligand:
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 36.25Å b: 59.68Å c: 62.599Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.138 0.136 0.166
Expression system: Homo sapiens

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