› 5y7y

X-ray diffraction
2.4Å resolution

Crystal structure of AhRR/ARNT complex

Released:
DOI: 10.2210/pdb5y7y/pdb
PDB entry 5y7y coloured by chain, front view.
PDB entry 5y7y coloured by chain, side view.
PDB entry 5y7y coloured by chain, top view.
Source organisms:
Primary publication:
The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription.
Sakurai S, Shimizu T, Ohto U
J Biol Chem 292 17609-17616 (2017)
PMID: 28904176

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109097 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Aryl hydrocarbon receptor repressor Chain: A
Molecule details ›
Chain: A
Length: 258 amino acids
Theoretical weight: 28.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A9YTQ3 (Residues: 27-280; Coverage: 36%)
Gene names: AHRR, BHLHE77, KIAA1234
Sequence domains:
Aryl hydrocarbon receptor nuclear translocator Chain: B
Molecule details ›
Chain: B
Length: 311 amino acids
Theoretical weight: 35.63 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BE97 (Residues: 82-464; Coverage: 39%)
Gene name: ARNT
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NE3A
Spacegroup: P41
Unit cell:
a: 78.362Å b: 78.362Å c: 129.784Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.234 0.268
Expression system: Spodoptera frugiperda

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Citations

15 review citations

COVID-19, an opportunity to reevaluate the correlation between long-term effects of anthropogenic pollutants on viral epidemic/pandemic events and prevalence.
Tsatsakis et al. (2020)
14 more

7 mentions without citation

bHLH-PAS Proteins: Their Structure and Intrinsic Disorder.
Kolonko et al. (2019)
6 more