› 5yy8

X-ray diffraction
1.98Å resolution

Crystal structure of the Kelch domain of human NS1-BP

Released:
DOI: 10.2210/pdb5yy8/pdb
PDB entry 5yy8 coloured by chain, front view.
PDB entry 5yy8 coloured by chain, side view.
PDB entry 5yy8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 Å resolution.
Guo L, Liu Y
Acta Crystallogr F Struct Biol Commun 74 174-178 (2018)
PMID: 29497022

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195397 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Influenza virus NS1A-binding protein Chain: A
Molecule details ›
Chain: A
Length: 328 amino acids
Theoretical weight: 37.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6Y0 (Residues: 330-642; Coverage: 49%)
Gene names: ARA3, FLARA3, HSPC068, IVNS1ABP, KIAA0850, KLHL39, NS1, NS1BP
Sequence domains: Kelch motif

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 15 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P3221
Unit cell:
a: 61.556Å b: 61.556Å c: 140.572Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.189 0.232
Expression system: Escherichia coli

Quick links

Citations

3 mentions without citation

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue.
Hushpulian et al. (2021)
2 more