› 5zck

X-ray diffraction
1.27Å resolution

Structure of the RIP3 core region

Released:
DOI: 10.2210/pdb5zck/pdb
PDB entry 5zck coloured by chain, front view.
PDB entry 5zck coloured by chain, side view.
PDB entry 5zck coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex.
Mompeán M, Li W, Li J, Laage S, Siemer AB, Bozkurt G, Wu H, McDermott AE
Cell 173 1244-1253.e10 (2018)
PMID: 29681455

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195261 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-interacting serine/threonine-protein kinase 3 Chain: A
Molecule details ›
Chain: A
Length: 4 amino acids
Theoretical weight: 401 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9Y572 (Residues: 458-461; Coverage: 1%)
Gene names: RIP3, RIPK3

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 4.813Å b: 17.151Å c: 29.564Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.139 0.137 0.152
Expression system: Not provided

Quick links

Citations

54 review citations

The molecular machinery of regulated cell death.
Tang et al. (2019)
53 more

1 mention without citation

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex.
Mompeán et al. (2018)