› 5ze3

X-ray diffraction
2.4Å resolution

Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state

Released:
DOI: 10.2210/pdb5ze3/pdb
PDB entry 5ze3 coloured by chain, front view.
PDB entry 5ze3 coloured by chain, side view.
PDB entry 5ze3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state.
Zhang X, Wang Q, Wu J, Wang J, Shi Y, Liu M
Proc Natl Acad Sci U S A 115 3828-3833 (2018)
PMID: 29581294

Function and Biology Details

Reaction catalysed: 
[Protein]-L-lysine + O(2) + H(2)O = [protein]-(S)-2-amino-6-oxohexanoate + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195243 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysyl oxidase homolog 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 457 amino acids
Theoretical weight: 51.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y4K0 (Residues: 318-774; Coverage: 61%)
Gene name: LOXL2
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand CA 2 x CA
Ligand NAG 2 x NAG
Ligand ZN 2 x ZN
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P21
Unit cell:
a: 73.095Å b: 61.487Å c: 137.883Å
α: 90° β: 102.33° γ: 90°
R-values:
R R work R free
0.218 0.217 0.239
Expression system: Homo sapiens

Quick links

Citations

9 review citations

The Role of Lysyl Oxidase Enzymes in Cardiac Function and Remodeling.
Rodríguez et al. (2019)
8 more

16 mentions without citation

Silver Ions as a Tool for Understanding Different Aspects of Copper Metabolism.
Puchkova et al. (2019)
15 more