› 5zgd

X-ray diffraction
1.4Å resolution

hnRNPA1 reversible amyloid core GFGGNDNFG (residues 209-217) determined by X-ray

Released:
DOI: 10.2210/pdb5zgd/pdb
PDB entry 5zgd coloured by chain, front view.
PDB entry 5zgd coloured by chain, side view.
PDB entry 5zgd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Gui X, Luo F, Li Y, Zhou H, Qin Z, Liu Z, Gu J, Xie M, Zhao K, Dai B, Shin WS, He J, He L, Jiang L, Zhao M, Sun B, Li X, Liu C, Li D
Nat Commun 10 2006 (2019)
PMID: 31043593

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140720 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 9 amino acids
Theoretical weight: 884 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09651 (Residues: 209-217; Coverage: 2%)
Gene names: HNRNPA1, HNRPA1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 4.869Å b: 27.263Å c: 35.311Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.126 0.122 0.159
Expression system: Not provided

Quick links

Citations

35 review citations

Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases.
Zhang et al. (2020)
34 more

1 mention without citation

Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Gui et al. (2019)