› 5zgg

Solution NMR

NMR structure of p75NTR transmembrane domain in complex with NSC49652

Released:
DOI: 10.2210/pdb5zgg/pdb
PDB entry 5zgg coloured by chain, ensemble of 10 models, front view.
PDB entry 5zgg coloured by chain, ensemble of 10 models, side view.
PDB entry 5zgg coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth.
Goh ETH, Lin Z, Ahn BY, Lopes-Rodrigues V, Dang NH, Salim S, Berger B, Dymock B, Senger DL, Ibáñez CF
Cell Chem Biol 25 1485-1494.e5 (2018)
PMID: 30293939

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139929 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor receptor superfamily member 16 Chains: A, B
Molecule details ›
Chains: A, B
Length: 34 amino acids
Theoretical weight: 3.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08138 (Residues: 244-277; Coverage: 9%)
Gene names: NGFR, TNFRSF16
Sequence domains: Tumor necrosis factor receptor member 16 trans-membrane domain

Ligands and Environments

1 bound ligand:
Ligand 9F6 1 x 9F6
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 47%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

3 review citations

In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target.
Malik et al. (2021)
2 more

1 mention without citation

AraC interacts with p75NTR transmembrane domain to induce cell death of mature neurons.
Lopes-Rodrigues et al. (2023)