› 5zid

X-ray diffraction
3Å resolution

Crystal Structure of human DPP-IV in complex with HL2

Released:
DOI: 10.2210/pdb5zid/pdb
PDB entry 5zid coloured by chain, front view.
PDB entry 5zid coloured by chain, side view.
PDB entry 5zid coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhu L, Li H, Wu F

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Dipeptidyl peptidase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 734 amino acids
Theoretical weight: 85.26 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27487 (Residues: 40-766; Coverage: 95%)
Gene names: ADCP2, CD26, DPP4
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand 9EL 2 x 9EL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P21
Unit cell:
a: 66.07Å b: 126.19Å c: 118.62Å
α: 90° β: 99.3° γ: 90°
R-values:
R R work R free
0.194 0.191 0.253
Expression system: Spodoptera frugiperda

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