› 5zsu

Electron Microscopy
4.25Å resolution

Structure of the human homo-hexameric LRRC8A channel at 4.25 Angstroms

Released:
DOI: 10.2210/pdb5zsu/pdb
PDB entry 5zsu coloured by chain, front view.
PDB entry 5zsu coloured by chain, side view.
PDB entry 5zsu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of the human volume-regulated anion channel LRRC8.
Kasuya G, Nakane T, Yokoyama T, Jia Y, Inoue M, Watanabe K, Nakamura R, Nishizawa T, Kusakizako T, Tsutsumi A, Yanagisawa H, Dohmae N, Hattori M, Ichijo H, Yan Z, Kikkawa M, Shirouzu M, Ishitani R, Nureki O
Nat Struct Mol Biol 25 797-804 (2018)
PMID: 30127360
Related structures: EMD-6952

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184895 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Volume-regulated anion channel subunit LRRC8A Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 818 amino acids
Theoretical weight: 95.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8IWT6 (Residues: 1-810; Coverage: 100%)
Gene names: KIAA1437, LRRC8, LRRC8A, SWELL1, UNQ221/PRO247
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.25Å
Relevant EMDB volumes: EMD-6952
Expression system: Homo sapiens

Quick links

Citations

12 review citations

Molecular Biology and Physiology of Volume-Regulated Anion Channel (VRAC).
Osei-Owusu et al. (2018)
11 more

9 mentions without citation

Biophysics and Structure-Function Relationships of LRRC8-Formed Volume-Regulated Anion Channels.
König et al. (2019)
8 more