› 6a69

Electron Microscopy
4.11Å resolution

Cryo-EM structure of a P-type ATPase

Released:
DOI: 10.2210/pdb6a69/pdb
PDB entry 6a69 coloured by chain, front view.
PDB entry 6a69 coloured by chain, side view.
PDB entry 6a69 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.
Gong D, Chi X, Ren K, Huang G, Zhou G, Yan N, Lei J, Zhou Q
Nat Commun 9 3623 (2018)
PMID: 30190470
Related structures: EMD-6987

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148820 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Plasma membrane calcium-transporting ATPase 1 Chain: A
Molecule details ›
Chain: A
Length: 1274 amino acids
Theoretical weight: 140.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20020 (Residues: 1-1117, 1118-1220; Coverage: 100%)
Gene names: ATP2B1, PMCA1
Sequence domains:
Neuroplastin Chain: B
Molecule details ›
Chain: B
Length: 282 amino acids
Theoretical weight: 31.33 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y639 (Residues: 146-398; Coverage: 68%)
Gene names: NPTN, SDFR1, SDR1
Sequence domains: Immunoglobulin domain

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.11Å
Relevant EMDB volumes: EMD-6987
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Signaling through Ca2+ Microdomains from Store-Operated CRAC Channels.
Barak et al. (2020)
7 more

10 mentions without citation

Primary Active Ca2+ Transport Systems in Health and Disease.
Chen et al. (2020)
9 more