› 6a6b

Electron Microscopy
3.07Å resolution

cryo-em structure of alpha-synuclein fiber

Released:
DOI: 10.2210/pdb6a6b/pdb
PDB entry 6a6b coloured by chain, front view.
PDB entry 6a6b coloured by chain, side view.
PDB entry 6a6b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy.
Li Y, Zhao C, Luo F, Liu Z, Gui X, Luo Z, Zhang X, Li D, Liu C, Li X
Cell Res 28 897-903 (2018)
PMID: 30065316
Related structures: EMD-6988

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153504 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 63 amino acids
Theoretical weight: 6.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P37840 (Residues: 37-99; Coverage: 45%)
Gene names: NACP, PARK1, SNCA
Sequence domains: Synuclein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.07Å
Relevant EMDB volumes: EMD-6988
Expression system: Escherichia coli K-12

Quick links

Citations

48 review citations

Half a century of amyloids: past, present and future.
Ke et al. (2020)
47 more

36 mentions without citation

Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.
Meade et al. (2019)
35 more