› 6acb

X-ray diffraction
2.8Å resolution

Function and Biology Details

Reaction catalysed: 
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131208 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cGMP-specific 3',5'-cyclic phosphodiesterase Chain: A
Molecule details ›
Chain: A
Length: 326 amino acids
Theoretical weight: 37.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O76074 (Residues: 535-860; Coverage: 37%)
Gene names: PDE5, PDE5A
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Ligands and Environments

4 bound ligands:
Ligand SO4 1 x SO4
Ligand ZN 1 x ZN
Ligand MG 1 x MG
Ligand 9T9 1 x 9T9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OXFORD DIFFRACTION NOVA
Spacegroup: P3121
Unit cell:
a: 74.577Å b: 74.577Å c: 132.092Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.198 0.268
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

Advancements in Phosphodiesterase 5 Inhibitors: Unveiling Present and Future Perspectives.
ElHady et al. (2023)
4 other articles