› 6ade

X-ray diffraction
3.15Å resolution

Crystal structure of phosphorylated mutant of glyceraldehyde 3-phosphate dehydrogenase from human placenta at 3.15A resolution

Released:
DOI: 10.2210/pdb6ade/pdb
PDB entry 6ade coloured by chain, front view.
PDB entry 6ade coloured by chain, side view.
PDB entry 6ade coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dilawari R, Singh PK, Raje M, Sharma S, Singh TP

Function and Biology Details

Reaction catalysed: 
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137625 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glyceraldehyde-3-phosphate dehydrogenase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 335 amino acids
Theoretical weight: 36.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04406 (Residues: 1-335; Coverage: 100%)
Gene names: CDABP0047, GAPD, GAPDH, OK/SW-cl.12
Sequence domains:
Structure domains: Dihydrodipicolinate Reductase; domain 2

Ligands and Environments


Cofactor: Ligand NAD 1 x NAD
No bound ligands
1 modified residue:
Ligand SEP 6 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: I222
Unit cell:
a: 90.78Å b: 131.68Å c: 220.64Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.239
Expression system: Escherichia coli

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