› 6ahz

Solution NMR

The NMR Structure of the Polysialyltranseferase Domain (PSTD) in Polysialyltransferase ST8siaIV

Released:
DOI: 10.2210/pdb6ahz/pdb
PDB entry 6ahz coloured by chain, ensemble of 20 models, front view.
PDB entry 6ahz coloured by chain, ensemble of 20 models, side view.
PDB entry 6ahz coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The Inhibition of Polysialyltranseferase ST8SiaIV Through Heparin Binding to Polysialyltransferase Domain (PSTD).
Peng LX, Liu XH, Lu B, Liao SM, Zhou F, Huang JM, Chen D, Troy FA, Zhou GP, Huang RB
Med Chem 15 486-495 (2019)
PMID: 30569872

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187639 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 4.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q92187 (Residues: 245-279; Coverage: 10%)
Gene names: PST, PST1, SIAT8D, ST8SIA4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: simulated annealing
Expression system: Not provided

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Citations

1 review citation

Re-Expression of Poly/Oligo-Sialylated Adhesion Molecules on the Surface of Tumor Cells Disrupts Their Interaction with Immune-Effector Cells and Contributes to Pathophysiological Immune Escape.
Jarahian et al. (2021)
3 other articles

3 mentions without citation

An in silico scientific basis for LL-37 as a therapeutic for Covid-19.
Lokhande et al. (2022)
2 more