› 6amw

Solution NMR

Abl1b Regulatory Module 'Activating' conformation

Released:
DOI: 10.2210/pdb6amw/pdb
PDB entry 6amw coloured by chain, ensemble of 20 models, front view.
PDB entry 6amw coloured by chain, ensemble of 20 models, side view.
PDB entry 6amw coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Atomic view of the energy landscape in the allosteric regulation of Abl kinase.
Saleh T, Rossi P, Kalodimos CG
Nat Struct Mol Biol 24 893-901 (2017)
PMID: 28945248

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 28.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P00519 (Residues: 6-12, 13-236; Coverage: 20%)
Gene names: ABL, ABL1, JTK7
Sequence domains:
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

11 review citations

The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases.
Shah et al. (2018)
10 more

4 mentions without citation

Chemical shift-based methods in NMR structure determination.
Nerli et al. (2018)
3 more