› 6aod

X-ray diffraction
1.8Å resolution

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230780 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
FXIa Antibody FAB Light Chain Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
FXIa Antibody FAB Heavy Chain Chain: B
Molecule details ›
Chain: B
Length: 229 amino acids
Theoretical weight: 24.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Coagulation factor XIa light chain Chain: C
Molecule details ›
Chain: C
Length: 245 amino acids
Theoretical weight: 27.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P03951 (Residues: 388-624; Coverage: 39%)
Gene name: F11
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

4 bound ligands:
Ligand SO4 4 x SO4
Ligand GOL 9 x GOL
Ligand CO 3 x CO
Ligand PO4 5 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: I422
Unit cell:
a: 136.127Å b: 136.127Å c: 175.956Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.182 0.207
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies.
Li et al. (2022)
1 other article

2 mentions without citation

Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.
Ely et al. (2018)
1 more