› 6arh

X-ray diffraction
1.6Å resolution

Crystal structure of Human NAL at a resolution of 1.6 Angstrom

Released:
DOI: 10.2210/pdb6arh/pdb
PDB entry 6arh coloured by chain, front view.
PDB entry 6arh coloured by chain, side view.
PDB entry 6arh coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pearce FG, Bundela R, Keown JR

Function and Biology Details

Reaction catalysed: 
Aceneneuramate = N-acetyl-D-mannosamine + pyruvate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189785 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-acetylneuraminate lyase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 338 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BXD5 (Residues: 1-320; Coverage: 100%)
Gene names: C1orf13, NPL
Sequence domains: Dihydrodipicolinate synthetase family
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
Ligand ACT 8 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 96.988Å b: 106.897Å c: 127.027Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.164 0.189
Expression system: Escherichia coli

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