› 6ash

X-ray diffraction
1.42Å resolution

Crystal structure of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution

Released:
DOI: 10.2210/pdb6ash/pdb
PDB entry 6ash coloured by chain, front view.
PDB entry 6ash coloured by chain, side view.
PDB entry 6ash coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Law S, Aguda A, Nguyen N, Brayer G, Bromme D

Function and Biology Details

Reaction catalysed: 
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154996 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin K Chain: A
Molecule details ›
Chain: A
Length: 215 amino acids
Theoretical weight: 23.51 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: P43235 (Residues: 115-329; Coverage: 69%)
Gene names: CTSK, CTSO, CTSO2
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

1 bound ligand:
Ligand 1XF 3 x 1XF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21
Unit cell:
a: 39.48Å b: 60.4Å c: 44.15Å
α: 90° β: 95.12° γ: 90°
R-values:
R R work R free
0.117 0.116 0.146
Expression system: Komagataella phaffii GS115

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