› 6atu

X-ray diffraction
2.4Å resolution

Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox

Released:
DOI: 10.2210/pdb6atu/pdb
PDB entry 6atu coloured by chain, front view.
PDB entry 6atu coloured by chain, side view.
PDB entry 6atu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Screening, large-scale production and structure-based classification of cystine-dense peptides.
Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK
Nat Struct Mol Biol 25 270-278 (2018)
PMID: 29483648

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo octadecamer
Assembly name:
PDBe Complex ID:
PDB-CPX-148807 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Elafin Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Length: 59 amino acids
Theoretical weight: 6.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P19957 (Residues: 61-117; Coverage: 60%)
Gene names: PI3, WAP3, WFDC14
Sequence domains:
Structure domains: Elafin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P41
Unit cell:
a: 71.333Å b: 71.333Å c: 214.444Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.248
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Miniproteins as a Powerful Modality in Drug Development.
Crook et al. (2020)
3 more

1 mention without citation

Screening, large-scale production and structure-based classification of cystine-dense peptides.
Correnti et al. (2018)