6atv

X-ray diffraction
1.75Å resolution

The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host protein-protein interactions

Released:
Source organisms:
Primary publication:
Molecular Mechanisms of Tight Binding through Fuzzy Interactions.
Biophys J 114 1313-1320 (2018)
PMID: 29590589

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-155435 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Adapter molecule crk Chain: A
Molecule details ›
Chain: A
Length: 58 amino acids
Theoretical weight: 6.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46108 (Residues: 134-191; Coverage: 19%)
Gene name: CRK
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Non-structural protein 1 Chain: M
Molecule details ›
Chain: M
Length: 15 amino acids
Theoretical weight: 1.59 KDa
Source organism: Orthomyxoviridae
Expression system: Not provided
UniProt:
  • Canonical: Q99AU3 (Residues: 210-221; Coverage: 5%)
Gene name: NS

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P6122
Unit cell:
a: 39.84Å b: 39.84Å c: 171.951Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.184 0.205
Expression systems:
  • Escherichia coli
  • Not provided