› 6ax5

Solution NMR

RPT1 region of INI1/SNF5/SMARCB1_HUMAN - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1.

Released:
DOI: 10.2210/pdb6ax5/pdb
PDB entry 6ax5 coloured by chain, ensemble of 20 models, front view.
PDB entry 6ax5 coloured by chain, ensemble of 20 models, side view.
PDB entry 6ax5 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication.
Dixit U, Bhutoria S, Wu X, Qiu L, Spira M, Mathew S, Harris R, Adams LJ, Cahill S, Pathak R, Rajesh Kumar P, Nguyen M, Acharya SA, Brenowitz M, Almo SC, Zou X, Steven AC, Cowburn D, Girvin M, Kalpana GV
Nat Commun 12 2743 (2021)
PMID: 33980829

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171401 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Chain: A
Molecule details ›
Chain: A
Length: 83 amino acids
Theoretical weight: 9.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12824 (Residues: 183-265; Coverage: 22%)
Gene names: BAF47, INI1, SMARCB1, SNF5L1
Sequence domains: SNF5 / SMARCB1 / INI1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 95%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Multimodal Functionalities of HIV-1 Integrase.
Engelman et al. (2022)
1 more

3 mentions without citation

Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome.
Wagner et al. (2020)
2 more