› 6axp

X-ray diffraction
2.48Å resolution

Structure of cetuximab with aminoheptanoic acid-linked n-octylarginine meditope variant

Released:
DOI: 10.2210/pdb6axp/pdb
PDB entry 6axp coloured by chain, front view.
PDB entry 6axp coloured by chain, side view.
PDB entry 6axp coloured by chain, top view.
Source organisms:
Primary publication:
Meditope-Fab interaction: threading the hole.
Bzymek KP, Ma Y, Avery KN, Horne DA, Williams JC
Acta Crystallogr F Struct Biol Commun 73 688-694 (2017)
PMID: 29199990

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-134632 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin kappa constant Chains: A, C
Molecule details ›
Chains: A, C
Length: 213 amino acids
Theoretical weight: 23.29 KDa
Source organism: Homo sapiens
Expression system: unidentified
UniProt:
  • Canonical: P01834 (Residues: 1-106; Coverage: 99%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chains: B, D
Molecule details ›
Chains: B, D
Length: 221 amino acids
Theoretical weight: 23.73 KDa
Source organism: Homo sapiens
Expression system: unidentified
UniProt:
  • Canonical: S6B291 (Residues: 20-116, 117-238; Coverage: 49%)
Sequence domains:
Structure domains: Immunoglobulins
meditope Chains: E, F
Molecule details ›
Chains: E, F
Length: 11 amino acids
Theoretical weight: 1.5 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 64.39Å b: 82.94Å c: 212.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.228
Expression systems:
  • unidentified
  • Not provided

Quick links

Citations

1 citations in other articles

Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag.
King et al. (2018)

1 mention without citation

Meditope-Fab interaction: threading the hole.
Bzymek et al. (2017)