› 6b0t

X-ray diffraction
2.8Å resolution

Structural Insights into the Induced-fit Inhibition of Fascin by a Small Molecule

Released:
DOI: 10.2210/pdb6b0t/pdb
PDB entry 6b0t coloured by chain, front view.
PDB entry 6b0t coloured by chain, side view.
PDB entry 6b0t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor.
Huang J, Dey R, Wang Y, Jakoncic J, Kurinov I, Huang XY
J Mol Biol 430 1324-1335 (2018)
PMID: 29573988

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172542 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fascin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 487 amino acids
Theoretical weight: 54.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16658 (Residues: 7-493; Coverage: 99%)
Gene names: FAN1, FSCN1, HSN, SNL
Sequence domains: Fascin domain
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand C7V 6 x C7V
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P2
Unit cell:
a: 102.577Å b: 59.255Å c: 293.651Å
α: 90° β: 90.03° γ: 90°
R-values:
R R work R free
0.267 0.265 0.303
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Role of actin cytoskeleton in podocytes.
Sever S. (2021)
5 more

3 mentions without citation

Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor.
Huang et al. (2018)
2 more