› 6b41

X-ray diffraction
2.61Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Menin Chain: A
Molecule details ›
Chain: A
Length: 550 amino acids
Theoretical weight: 61.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00255 (Residues: 2-610; Coverage: 90%)
Gene names: MEN1, SCG2
Sequence domains: Menin

Ligands and Environments

2 bound ligands:
Ligand CJV 1 x CJV
Ligand 7PR 4 x 7PR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: I41
Unit cell:
a: 153.92Å b: 153.92Å c: 81.618Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.252
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Epigenetic modifications of histones in cancer.
Zhao et al. (2019)
13 more

4 mentions without citation

Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins.
Li et al. (2021)
3 more