› 6b79

X-ray diffraction
1.8Å resolution

Curved pair of sheets formed from SOD1 residues 28-38 with familial mutation G37R.

Released:
DOI: 10.2210/pdb6b79/pdb
PDB entry 6b79 coloured by chain, front view.
PDB entry 6b79 coloured by chain, side view.
PDB entry 6b79 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.
Sangwan S, Sawaya MR, Murray KA, Hughes MP, Eisenberg DS
Protein Sci 27 1231-1242 (2018)
PMID: 29453800

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132498 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Cu-Zn] Chains: A, B
Molecule details ›
Chains: A, B
Length: 11 amino acids
Theoretical weight: 1.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00441 (Residues: 29-39; Coverage: 7%)
Gene name: SOD1

Ligands and Environments

1 bound ligand:
Ligand ORA 1 x ORA
1 modified residue:
Ligand A8E 2 x A8E

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 56.94Å b: 11.64Å c: 44.93Å
α: 90° β: 127.32° γ: 90°
R-values:
R R work R free
0.234 0.23 0.267
Expression system: Not provided

Quick links

Citations

2 review citations

Exploring amyloid oligomers with peptide model systems.
Samdin et al. (2021)
1 more

2 mentions without citation

Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants.
Huai et al. (2019)
1 more