› 6b8g

X-ray diffraction
1.13Å resolution

Twice-Contracted Human Heavy-Chain Ferritin Crystal-Hydrogel Hybrid

Released:
DOI: 10.2210/pdb6b8g/pdb
PDB entry 6b8g coloured by chain, front view.
PDB entry 6b8g coloured by chain, side view.
PDB entry 6b8g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks.
Zhang L, Bailey JB, Subramanian RH, Groisman A, Tezcan FA
Nature 557 86-91 (2018)
PMID: 29720635

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin heavy chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02794 (Residues: 2-183; Coverage: 100%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain
Structure domains: Ferritin

Ligands and Environments

2 bound ligands:
Ligand FE 2 x FE
Ligand CA 11 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: F432
Unit cell:
a: 179.95Å b: 179.95Å c: 179.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.104 0.102 0.121
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Protein Assembly by Design.
Zhu et al. (2021)
7 more

1 mention without citation

Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks.
Zhang et al. (2018)