6b8p

X-ray diffraction
2.2Å resolution

Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-143929 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Potassium voltage-gated channel subfamily KQT member 4 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 82 amino acids
Theoretical weight: 9.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56696 (Residues: 325-367, 370-398; Coverage: 11%)
Gene name: KCNQ4
Calmodulin-1 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: I222
Unit cell:
a: 108.141Å b: 142.875Å c: 164.082Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.207 0.24
Expression system: Escherichia coli