6b8q

X-ray diffraction
2.6Å resolution

Crystal Structure of the Mg2+/CaM:Kv7.5 (KCNQ5) AB domain complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-143963 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Potassium voltage-gated channel subfamily KQT member 5 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 75 amino acids
Theoretical weight: 8.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NR82 (Residues: 361-398, 401-545; Coverage: 7%)
Gene name: KCNQ5
Calmodulin-1 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 70.821Å b: 116.845Å c: 119.812Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.27
Expression system: Escherichia coli