› 6ba4

X-ray diffraction
1.95Å resolution

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT8 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 34.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H7Z6 (Residues: 174-449; Coverage: 60%)
Gene names: KAT8, MOF, MYST1, PP7073
Sequence domains:

Ligands and Environments


Cofactor: Ligand ACO 1 x ACO
3 bound ligands:
Ligand ZN 1 x ZN
Ligand NA 3 x NA
Ligand 7L1 1 x 7L1
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 46.363Å b: 57.925Å c: 120.045Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.213
Expression system: Escherichia coli

Quick links

Citations

42 review citations

Hepatocellular Senescence: Immunosurveillance and Future Senescence-Induced Therapy in Hepatocellular Carcinoma.
Liu et al. (2020)
41 more

2 mentions without citation

Lysine Acetyltransferase Inhibitors From Natural Sources.
Fiorentino et al. (2020)
1 more