› 6bb4

X-ray diffraction
2.1Å resolution

Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope.

Released:
DOI: 10.2210/pdb6bb4/pdb
PDB entry 6bb4 coloured by chain, front view.
PDB entry 6bb4 coloured by chain, side view.
PDB entry 6bb4 coloured by chain, top view.
Source organisms:
Primary publication:
Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein.
Chukwu JE, Pedersen JT, Pedersen LØ, Volbracht C, Sigurdsson EM, Kong XP
Sci Rep 8 6209 (2018)
PMID: 29670132

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210475 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Mouse monoclonal antibody C5.2 Fab light chain Chains: L, M, N
Molecule details ›
Chains: L, M, N
Length: 213 amino acids
Theoretical weight: 23.57 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Mouse monoclonal antibody C5.2 Fab heavy chain Chains: H, I, J
Molecule details ›
Chains: H, I, J
Length: 220 amino acids
Theoretical weight: 23.73 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Microtubule-associated protein tau Chains: P, Q, R
Molecule details ›
Chains: P, Q, R
Length: 23 amino acids
Theoretical weight: 2.63 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 703-725; Coverage: 3%)
Gene names: MAPT, MAPTL, MTBT1, TAU

Ligands and Environments

1 bound ligand:
Ligand PO4 3 x PO4
1 modified residue:
Ligand SEP 6 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL14-1
Spacegroup: C2
Unit cell:
a: 161.156Å b: 40.535Å c: 228.064Å
α: 90° β: 104.07° γ: 90°
R-values:
R R work R free
0.218 0.218 0.27
Expression system: Not provided

Quick links

Citations

5 review citations

Tau immunotherapies: Lessons learned, current status and future considerations.
Sandusky-Beltran et al. (2020)
4 more

2 mentions without citation

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status.
Pinzi et al. (2023)
1 more