› 6bbp

Electron Microscopy
35Å resolution

Model for compact volume of truncated monomeric Cytohesin-3 (Grp1; amino acids 63-399) E161A 6GS Arf6 Q67L fusion protein

Released:
DOI: 10.2210/pdb6bbp/pdb
PDB entry 6bbp coloured by chain, front view.
PDB entry 6bbp coloured by chain, side view.
PDB entry 6bbp coloured by chain, top view.
Source organisms:
Primary publication:
Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors.
Malaby AW, Das S, Chakravarthy S, Irving TC, Bilsel O, Lambright DG
Structure 26 106-117.e6 (2018)
PMID: 29276036
Related structures: EMD-7077

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126700 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosylation factor 6; Cytohesin-3 Chain: A
Molecule details ›
Chain: A
Length: 520 amino acids
Theoretical weight: 60.29 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: O08967 (Residues: 63-399; Coverage: 85%)
  • Canonical: P62330 (Residues: 2-173; Coverage: 98%)
Gene names: ARF6, Cyth3, Grp1, Pscd3
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand GTP 1 x GTP
Ligand MG 1 x MG
Ligand 4IP 1 x 4IP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 35Å
Relevant EMDB volumes: EMD-7077
Expression system: Escherichia coli

Quick links

Citations

4 citation in other articles

Interaction of the N terminus of ADP-ribosylation factor with the PH domain of the GTPase-activating protein ASAP1 requires phosphatidylinositol 4,5-bisphosphate.
Roy et al. (2019)
3 more

2 mentions without citation

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA.
Chen et al. (2017)
1 more