› 6bcs

X-ray diffraction
2.1Å resolution

LilrB2 D1D2 domains complexed with benzamidine

Released:
DOI: 10.2210/pdb6bcs/pdb
PDB entry 6bcs coloured by chain, front view.
PDB entry 6bcs coloured by chain, side view.
PDB entry 6bcs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.
Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L
Nat Chem 10 1213-1221 (2018)
PMID: 30297750

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185380 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukocyte immunoglobulin-like receptor subfamily B member 2 Chain: A
Molecule details ›
Chain: A
Length: 198 amino acids
Theoretical weight: 22.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N423 (Residues: 24-220; Coverage: 34%)
Gene names: ILT4, LILRB2, LIR2, MIR10
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand BEN 4 x BEN
Ligand CL 2 x CL
Ligand DMS 2 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P41212
Unit cell:
a: 57.05Å b: 57.05Å c: 101.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.182 0.233
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease.
Guo et al. (2020)
6 more

2 mentions without citation

Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.
Cao et al. (2018)
1 more