› 6bf2

Solution NMR

Solution structure of a Bcl-xL S62E mutant

Released:
DOI: 10.2210/pdb6bf2/pdb
PDB entry 6bf2 coloured by chain, ensemble of 20 models, front view.
PDB entry 6bf2 coloured by chain, ensemble of 20 models, side view.
PDB entry 6bf2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Regulation of apoptosis by an intrinsically disordered region of Bcl-xL.
Follis AV, Llambi F, Kalkavan H, Yao Y, Phillips AH, Park CG, Marassi FM, Green DR, Kriwacki RW
Nat Chem Biol 14 458-465 (2018)
PMID: 29507390

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170518 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 212 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07817 (Residues: 1-209; Coverage: 90%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 77%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians.
Borrás et al. (2020)
4 more

3 mentions without citation

The Structural Biology of Bcl-xL.
Lee et al. (2019)
2 more