Function and Biology Details
Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Tetratricopeptide repeat
- Tetratricopeptide-like helical domain superfamily
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- Phosphoinositide 3-kinase, accessory (PIK) domain
- Hyccin
- Phosphatidylinositol 3/4-kinase, conserved site
- Tetratricopeptide repeat protein 7, N-terminal
- Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
5 more domains
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-154638 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Phosphatidylinositol 4-kinase alpha
Molecule details ›
Chain: A
Length: 1647 amino acids
Theoretical weight: 173.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 1647 amino acids
Theoretical weight: 173.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P42356 (Residues: 932-2102; Coverage: 56%)
Sequence domains:
Tetratricopeptide repeat protein 7B
Molecule details ›
Chains: B, F
Length: 863 amino acids
Theoretical weight: 96.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 863 amino acids
Theoretical weight: 96.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q86TV6 (Residues: 1-843; Coverage: 100%)
Sequence domains:
Hyccin
Phosphatidylinositol 4-kinase alpha
Molecule details ›
Chain: E
Length: 1648 amino acids
Theoretical weight: 173.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 1648 amino acids
Theoretical weight: 173.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P42356 (Residues: 932-2102; Coverage: 56%)
Sequence domains:
