› 6bqg

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142059 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5-hydroxytryptamine receptor 2C; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 452 amino acids
Theoretical weight: 51.31 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P28335 (Residues: 40-245, 301-393; Coverage: 70%)
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
Gene names: HTR1C, HTR2C, cybC
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ERM 1 x ERM
Ligand OLC 1 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Unit cell:
a: 49.84Å b: 94.58Å c: 145.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.263 0.261 0.291
Expression system: Spodoptera frugiperda

Quick links

Citations

21 review citations

Mechanisms of signalling and biased agonism in G protein-coupled receptors.
Wootten et al. (2018)
20 more

36 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
35 more