› 6brw

X-ray diffraction
2.03Å resolution

JAK2 JH2 in complex with XMU-MP-1

Released:
DOI: 10.2210/pdb6brw/pdb
PDB entry 6brw coloured by chain, front view.
PDB entry 6brw coloured by chain, side view.
PDB entry 6brw coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Puleo DE, Schlessinger J

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130063 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK2 Chain: A
Molecule details ›
Chain: A
Length: 289 amino acids
Theoretical weight: 33.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60674 (Residues: 536-812; Coverage: 25%)
Gene name: JAK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand 5BS 1 x 5BS
Ligand GOL 1 x GOL
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 44.386Å b: 57.147Å c: 60.398Å
α: 90° β: 110.24° γ: 90°
R-values:
R R work R free
0.197 0.194 0.25
Expression system: Spodoptera frugiperda

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