› 6bt5

X-ray diffraction
2.92Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 479 amino acids
Theoretical weight: 53.51 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00222 (Residues: 37-514; Coverage: 55%)
Gene names: GPRC1H, GRM8, MGLUR8
Sequence domains: Receptor family ligand binding region

Ligands and Environments

2 bound ligands:
Ligand E7P 2 x E7P
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: I222
Unit cell:
a: 113.65Å b: 166.008Å c: 196.038Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.254 0.253 0.267
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Computational Drug Design Applied to the Study of Metabotropic Glutamate Receptors.
Llinas Del Torrent et al. (2019)

1 mention without citation

In silico binding affinity prediction for metabotropic glutamate receptors using both endpoint free energy methods and a machine learning-based scoring function.
Zhai et al. (2022)