› 6bvz

X-ray diffraction
2.3Å resolution

Importin alpha 3 in cargo free state

Released:
DOI: 10.2210/pdb6bvz/pdb
PDB entry 6bvz coloured by chain, front view.
PDB entry 6bvz coloured by chain, side view.
PDB entry 6bvz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Smith KM, Tsimbalyuk S, Edwards MR, Cross EM, Batra J, Soares da Costa TP, Aragão D, Basler CF, Forwood JK
Nat Commun 9 3703 (2018)
PMID: 30209309

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126366 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Importin subunit alpha-3 Chain: A
Molecule details ›
Chain: A
Length: 459 amino acids
Theoretical weight: 50.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00629 (Residues: 64-521; Coverage: 88%)
Gene names: KPNA4, QIP1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 47.118Å b: 53.229Å c: 91.309Å
α: 90° β: 92.86° γ: 90°
R-values:
R R work R free
0.251 0.25 0.268
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Karyopherin-mediated nucleocytoplasmic transport.
Wing et al. (2022)
8 more

2 mentions without citation

MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity.
Munasinghe et al. (2022)
1 more