Function and Biology Details
Reactions catalysed:
Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Somatomedin B domain
- DNA/RNA non-specific endonuclease
- Alkaline-phosphatase-like, core domain superfamily
- Somatomedin B-like domain superfamily
- Extracellular Endonuclease, subunit A
- His-Me finger superfamily
- DNA/RNA non-specific endonuclease superfamily
- Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127027 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Molecule details ›
Chains: A, B
Length: 838 amino acids
Theoretical weight: 96.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 838 amino acids
Theoretical weight: 96.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
O14638 (Residues: 48-875; Coverage: 95%)
Sequence domains:
Ligands and Environments
Experiments and Validation Details
X-ray source:
CLSI BEAMLINE 08ID-1
Spacegroup:
P21
Expression system: Spodoptera frugiperda
